That Risky Business closed on Sunday to make way for the new-to-Tucson concept, which will launch later this summer, according to a press release.
It will be one of more than 94 locations throughout the United States and Canada, including four in the Phoenix area.
The first Tilted Kilt opened in the Las Vegas Rio Hotel and Casino in 2003.
The brand is coming to Tucson, courtesy of restaurant owners Wes Harris and Bob Raynor.
Harris already owns a Tilted Kilt in Boise, Idaho.
Raynor owns the other two Risky Business locations in Tucson, one at 6866 E. Sunrise Drive and the other at 8848 E. Tanque Verde Road. They will remain open.
Aside from the pub grub, including dishes such as the roasted garlic fries and Irish nachos topped in a Guinness beer cheese sauce, Tilted Kilt was also conceived as a "pub staffed with beautiful servers in sexy plaid kilts and matching plaid bras,” according to the restaurant's website.