PHOENIX - Paul Goldschmidt homered twice, and the Diamondbacks beat the Reds 11-5 Friday night in Johnny Cueto's worst outing in three seasons.
Goldschmidt drove in three runs to raise his NL-leading RBI total to 65. Gerardo Parra hit a leadoff home run for Arizona, and Jason Kubel tied his career high with four hits.
Kubel doubled in a run and scored twice.
Cueto (4-1) went 4 1/3 innings and allowed seven runs, his most since Milwaukee scored eight against him on Sept. 22, 2010. The 11 hits off him matched his career worst.
Jay Bruce hit his 150th career home run for the Reds. Joey Votto drove in two runs with a long homer and a double.
Will Harris (1-0) got one out in relief of starter Wade Miley to get the victory.
Goldschmidt has four homers in four games and 19 for the year, one fewer than he had last season. He hit a two-run shot off Cueto in the fifth and a solo homer off Curtis Partch in the sixth for his third two-homer game of the season.
"That was a great job tonight up and down the lineup," Goldschmidt said. "We've got the talent to do it. ... Sometimes we're going to struggle and sometimes we're going to hit the ball well."
Cueto, in his second outing since returning from his second stint on the disabled list this season, lost to Arizona for the first time. He had been 5-0 with a 1.66 ERA in six starts against the Diamondbacks. The seven runs he allowed Friday equaled the total he gave up combined in his six other starts against them.
Things began badly for the Cincinnati ace when Parra pulled Cueto's 2-2 pitch into the right field seats for his fifth career leadoff home run, all this season.
In the second, Kubel led off with a single, then Didi Gregorius singled with one out to put runners at first and second. Miley struck out, but Parra walked to load the bases. Willie Bloomquist, hitless in his previous 11 at-bats, singled to center to bring in two runs, and Arizona led 3-0.
In the fourth, Bruce hit Miley's 0-1 pitch far into the seats in right field for his 16th home run to cut it to 3-1. The Reds tied it in the fifth .
Earlier in the fifth, Miley slipped on his follow through, prompting a visit from the trainer. He stayed in the game, for the time being. He threw 104 pitches in 4 2/3 innings, allowing three runs and five hits with four walks and five strikeouts.
Bloomquist led off the Arizona fifth with a single, then Goldschmidt hit one to the opposite field over the fence in right to put the Diamondbacks back on top for good, 5-3. Miguel Montero followed with a single, then after Cody Ross struck out, Kubel singled, and Cueto's night was finished.
"He's huge for our team," Arizona manager Kirk Gibson said about Goldschmidt. "I don't think anybody else has over 20-some RBIs, Goldy's in the 60s."
• Diamondbacks righty Zeke Spruill, called up from Triple-A Reno earlier in the day, pitched a scoreless inning of relief in his major-league debut. The Diamondbacks designated infielder Josh Wilson for assignment.
• In the series' prime pitching matchup tonight, the Reds send Mike Leake (7-3, 2.64 ERA) to the mound, and Arizona goes with Patrick Corbin (9-0, 2.28). Corbin will make his fourth try to go to 10-0 after no-decisions in his last three starts.
• Bruce has homered in six of his last eight games.
• What: Reds at Diamondbacks
• When: 4:15 p.m.
• TV; radio: Ch 11; 1490-AM, 104.9-FM