A single-vehicle crash on West Prince Road near Interstate 10 is expected to restrict traffic until about midnight.
The crash at North Runway Drive and Prince, west of North Romero Road, occurred shortly before 6 p.m. and sent two female passengers to the hospital with serious, not life-threatening injuries, said Sgt. Chris Widmer, a Tucson Police Department spokesman.
The driver of the car sustained minor injuries.
Widmer said Runway Drive remains closed in both directions, and westbound Prince is closed.