Two U.S. citizens and three Mexican nationals were arrested in separate drug smuggling incidents Friday and Saturday.

All total, they tried to smuggle 107 pounds of cocaine, heroin and methamphetamine into the United States through the Port of Nogales.

A 33-year-old woman from Nogales, Arizona, was stopped Friday while trying to walk across the border. U.S. Customs and Border Protection officers searched her and found in her possession more than six pounds of heroin worth nearly $87,000, according to a CBP news release.

At about the same time, a drug-sniffing dog detected narcotics in a Ford SUV driven by a 42-year-old man from Mexico. Officers found 11 packages of cocaine, weighing a total of 27.5 pounds, under the rear seats. The drugs had an estimated value exceeding $288,000.

Soon after, a 25-year-old Tucson woman driving a Chevrolet truck was stopped for inspection. A narcotics detection dog sniffed out 22 packages containing $91,000 worth of meth and five packages with more than $135,700 worth of cocaine hidden in the seats of the truck.

Friday night a narcotics dog alerted to drugs in a Dodge sedan driven by a 21-year-old woman from Mexico. Officers found more than 11.5 pounds of heroin worth in excess of $162,000 in the oil pan.

Saturday officers found nearly 19 pounds of meth, worth close to $57,000, in the rear quarter panel of a Ford sedan driven by a 23-year-old woman from Mexico.

Officers seized all drugs and vehicles and turned the suspects over to U.S. Immigration and Customs Enforcement’s Homeland Security Investigations.