Patterns ID'd in women's cancers

Study quantifies risks, including weight, smoking
2013-08-01T00:00:00Z Patterns ID'd in women's cancersKaren Kaplan Los Angeles Times Arizona Daily Star
August 01, 2013 12:00 am  • 

Women, wouldn't you like to know your precise risk of developing breast cancer, ovarian cancer and endometrial cancer? And wouldn't you like to know changes to make in your life to reduce that risk?

Researchers have published a study in the journal PLOS Medicine that takes a significant step toward that goal.

Ruth Pfeiffer, a senior investigator in the National Cancer Institute's Division of Cancer Epidemiology and Genetics, and colleagues focused on the predictive value of more than a dozen variables, including a woman's body mass index, number of children she has, how long she took birth control pills, whether she used hormone therapy to treat symptoms of menopause, family history of gynecological cancers, and use of cigarettes and alcohol.

They examined those variables in tens of thousands of women who participated in two long-term health studies and used statistics to look for patterns that could explain why some women were diagnosed with cancer and others were not.

The breast cancer model performed the best. Among a group of 56,638 women who were part of the Nurses' Health Study, the researchers predicted a total of 2,930 breast cancer cases. In real life, there were 2,934. However, although the new model got the total number almost exactly right, it "significantly underestimated the number of breast cancers in premenopausal women," the study noted.

The model for ovarian cancer worked pretty well too. It predicted 406 cases, about 8 percent higher than the 377 cases that were actually diagnosed.

The model for endometrial cancer was further off the mark. It anticipated 640 cases among the nurses, though in real life there were only 532 cases.

Generally speaking, women with lower BMIs had lower cancer risk. Compared with women with similar BMIs who were nonsmokers, smokers had higher cancer risk too.

You'd need a time machine to change other variables linked to cancer risk. For instance, women who took birth control pills tended to have higher cancer risk than women who didn't. So did women who used hormone replacement therapy. Women who had three or four children tended to have lower cancer risk than women who had one, and it helped if they had their first child in their 20s instead of in their 30s or 40s.

The researchers noted some caveats. All of the women used to develop the models were white and at least 50 years old, and none had mutations in their BRCA1 and BRCA2 genes that are known to boost the risk of breast or ovarian cancer.

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