Promising TB vaccine proves ineffective

2013-02-05T00:00:00Z Promising TB vaccine proves ineffectiveThe Associated Press The Associated Press
February 05, 2013 12:00 am  • 

LONDON - The world's most advanced tuberculosis vaccine failed to protect babies against the infectious disease, according to a new study.

The vaccine, MVA85A, was designed to improve protection from the only existing tuberculosis vaccine, BCG, which is routinely given to newborns. Though the new vaccine appeared safe, scientists found no proof it prevented tuberculosis, an airborne disease that kills more than 1 million people worldwide every year.

Previous tests of the vaccine in adults had been promising. There are a dozen other TB vaccines currently being tested.

"It's pretty disappointing," said Dr. Jennifer Cohn, a medical coordinator at Doctors Without Borders, who was not part of the study. "Infants are at really high risk of TB, but this doesn't seem to offer them any protection."

MVA85A was developed at Oxford University and was tested in nearly 2,800 infants in South Africa who had already been given a BCG shot, between 2009 and 2011. About half of the babies got the new vaccine while the other half got a placebo.

They were followed for up to three years. The vaccine's efficacy rate was about 17 percent.

The study was paid for by Aeras, the Wellcome Trust and the Oxford-Emergent Tuberculosis Consortium. The results were published online Monday in the journal Lancet.

Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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