Study: Hyperactive brain cells may be early hint of autism

2013-06-05T00:00:00Z Study: Hyperactive brain cells may be early hint of autismGeoffrey Mohan Los Angeles Times Arizona Daily Star
June 05, 2013 12:00 am  • 

LOS ANGELES - Hyperactive brain cells firing together could be an early indicator of autism and developmental disabilities, a team of UCLA researchers has found.

Networks of neurons were found to be firing in a highly synchronized and seemingly unrelenting fashion, even through sleep, in the brains of juvenile mice that have a genetic abnormality similar to one that causes mental retardation and autism symptoms in humans, according to the research published online Monday in Nature Neuroscience.

Without independently firing neurons, the human brain would be about as functionally complicated as a digital switch. With it, we compose poetry and send robotic carts to Mars.

"If you want to code information, you can't just have all the cells fire together or not, because then that's just binary. It goes up and down," said UCLA neuroscientist Carlos Portera-Cailliau, a lead author of the report. "But if you have billions of neurons, all firing independently or in small clusters, then you can code a lot of information."

That "de-synchronization" was greatly diminished in the neocortex of the juvenile mice that had been altered so that they lack the same protein known to cause mental retardation and autistic behaviors in humans.

These so-called Fmr1 Knockout mice, named for the gene that is knocked out, exhibit autism behaviors, among them social deficits - they don't go over and sniff and examine a new mouse introduced to the cage, like wild mice would.

The researchers inserted a transparent panel in the skulls of the mice so they could put them under a sophisticated microscope that would reveal how neurons were firing.

"It looks like Christmas lights," Portera-Cailliau said.

But the Christmas lights of the young mice were still blinking away during sleep, a crucial time when the brain works on its database - consolidating memory, which is vital for cognition and behavioral response. And far more of the neurons fired in synchrony than would in a normal brain, the researchers found.

Neurons of humans fire synchronously in utero, but sometime before birth they begin to fire independently. "This transition is really important," Portera-Cailliau said. "If you don't have this transition then computations in the brain are going to be abnormal."

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