STORRS, Conn. — Kaleena Mosqueda-Lewis has struggled this season with injury and illness. But everything felt fine on Tuesday night.

UConn’s 6-foot junior scored 20 points, pulled down 10 rebounds, and had 10 assists to lead the Huskies (36-0) to a 91-52 rout of Saint Joseph’s in the second round of the NCAA tournament.

It was the second triple-double for UConn this year, the third in program history, and just the 14th in the history of the women’s NCAA tournament.

“I’m fine now,” said Mosqueda-Lewis, who missed 12 games this season with an elbow injury and later a bout with mononucleosis. “I struggled so much with my confidence. Now I’m confident, and I’m out there playing relaxed.”

She led five players in double figures for Connecticut, which won its 42nd straight game.

Breanna Stewart added 21 points and 11 rebounds, and Bria Hartley also chipped in 20 points for the defending national champions, who are trying to win a record ninth NCAA tournament.

Erin Shields and Sarah Fairbanks each had 12 points to lead Saint Joseph’s, which finished the year at 23-10. Natasha Cloud had 10 points and six assists for the Hawks.

UConn will face 12th-seeded BYU in Lincoln, Neb., on Saturday. The Cougars upset Nebraska in the second round, sparing the Huskies a date with the Cornhuskers on their home court.

Mosqueda-Lewis connected on eight of her 14 shots, and was 3 of 5 from three-point range. Stefanie Dolson added 17 points and six rebounds.

She had UConn’s other triple-double this season, scoring 26 points, grabbing 13 rebounds, and dishing out 11 assists in a win over Oregon in November.

Dolson scored off the opening tip, and UConn never trailed. A pair of three-pointers from Jefferson and Mosqueda-Lewis made it 8-0.

Fairbanks ended the opening 10-0 UConn run with a layup to get the Hawks on the board.

“When they come off making four threes to start the game, we’re going to have our hands full,” Hawks coach Cindy Griffin said. “We were always playing catch-up.”

The Huskies hit five of their first six shots from behind the arc. Moriah Jefferson gave the Huskies their first 20-point lead at 36-16 with an old-fashioned three-point play on a drive to the basket.

It was the ninth time this season that UConn has put five players into double figures.

No. 4 Maryland 69, No. 5 Texas 64: In College Park, Md., Alyssa Thomas scored all 16 of her points in the second half, and the Terrapins (26-6) squeezed past cold-shooting Texas in the Louisville Regional to reach the Sweet 16 of the NCAA women’s tournament for the third consecutive year.

Krystle Henderson led Texas (22-12) with 14 points.

No. 4 North Carolina 62, No. 5 Michigan State 53: In Chapel Hill, N.C., freshman Diamond DeShields had 24 points and a season-high 12 rebounds to lead the Tar Heels (26-9) to the win in the Stanford Regional matchup. 

Jasmine Hines led the Spartans (23-10) with 16 points.

No. 3 Penn State 83, No. 11 Florida 61: In State College, Pa., Maggie Lucas and Dara Taylor each scored 22 points to pace Penn State (24-7) in the Stanford Regional.

Lucas, the two-time Big Ten Player of the Year, surpassed the 2,500 career-point milestone and led the Lady Lions to the NCAA tournament regional semifinal for the second time in three seasons.

“That we’re able to share it with the fans, it’s just a whole better feeling,” Lucas said. “It’s a great way to go out of the Bryce Jordan Center.”

Ariel Edwards added 16 points for Penn State. The Lady Lions are in the Sweet 16 for the 13th time.

Kayla Lewis led Florida (20-13) with 20 points.

No. 3 Louisville 83, No. 6 Iowa 53: In Iowa City, Ia., Shoni Schimmel had 26 points, seven assists and five steals to help the Cardinals (32-4) thump the host Hawkeyes and earn their fifth trip to the Sweet 16 under coach Jeff Walz.

Antonita Slaughter added 17 points on five threes for Louisville, which advanced to Sunday’s regional semifinal at home.

Freshman Ally Disterhoft had 15 points for Iowa (27-9), which finished just 1 of 16 from three-point range.

No. 1 South Carolina 78, No. 9 Oregon State 69: In Seattle, Aleighsa Welch had 21 points and 11 rebounds, Tiffany Mitchell added 20 points and 10 boards, and the Gamecocks (29-4) used their size and athleticism to overwhelm Oregon State in a Stanford Regional matchup.

A year after getting upset by a 12-seed in the second-round of the tournament, the Gamecocks are headed to the Sweet 16 for the second time in three years under coach Dawn Staley.

Jamie Weisner led Oregon State (24-11) with 21 points.

No. 3 Texas A&M 85, No. 11 James Madison 69: In College Station, Texas, Courtney Williams scored 23 points and Karla Gilbert added 20 points with 15 rebounds to help the Aggies (26-8) to the victory in Lincoln Regional action.

The Aggies used an 8-2 run to build a 10-point lead early in the second half, and answered each time James Madison cut the advantage.

The Dukes got within seven points with about seven minutes remaining, but A&M used an 8-0 run to make it 81-66.

Kirby Burkholder led 11th-seeded James Madison (29-6) with 20 points and 10 rebounds.