OKLAHOMA CITY - From the opening tip of the season, there was only one question in women's college basketball: How do you stop Brittney Griner?
Louisville found the answer Sunday night, pulling off one of the biggest upsets in NCAA tournament history.
Considered a lock for the Final Four - and prohibitive favorites to win a second straight championship - Griner and her Lady Bears got bounced 82-81 by fifth-seeded Louisville.
Baylor (34-2) had won 32 straight games behind Griner, among the greatest players ever in her sport. But the 6-foot-8-inch star didn't make a basket until the second half, then committed a foul with 2.6 seconds left that gave Louisville a chance to win.
Monique Reid made those two foul shots, rescuing the Cardinals (27-8) after they squandered a 17-point lead in the last 7 1/2 minutes.
Louisville will play Tennessee in the regional final on Tuesday for a berth in the Final Four.
Odyssey Sims scored 29 points, including two free throws with 9.1 seconds to go that put Baylor ahead 81-80.
Sims had one more chance to save the season, but she was off-target and late on a desperation heave.
Sims dropped to the floor after her miss, pulling her jersey over her face and kicking her legs as she lay flat on her back.
Griner squatted near her and slapped the floor with both hands before pulling Sims up to her feet.
It was a stunning end of a remarkable college career for Griner, the second-highest scoring player in NCAA history.
"I'm just sad," Griner said. "I didn't do what I needed to do to get my team to the Elite 8 and just disappointment in myself."
Griner, who had averaged 33 points in Baylor's first two games in the tournament, didn't make a basket until she converted a putback with 15:20 left in the second half. She wound up with 14 points and 10 rebounds.
• No. 2 Tennessee 74, No. 6 Oklahoma 59: In Oklahoma City, Kamiko Williams scored 15 points, Cierre Burdick had 13 and Tennessee (27-7) won in the regional semifinals.
The Lady Vols opened a 20-point lead in the first half and never let Oklahoma make a comeback.
• No. 1 Notre Dame 93, No. 12 Kansas 63: In Norfolk, Va., Skylar Diggins scored 22 of her 27 points by halftime and became the school's career scoring leader, leading the Fighting Irish in the semifinals of the Norfolk Regional. Notre Dame will play No. 2 seed Duke on Tuesday for a berth in the Final Four.
• No. 2 Duke 53, No. 6 Nebraska 45: In Norfolk, Va., Tricia Liston scored 17 points and Duke shook off a slow start to beat Nebraska in the semifinals of the Norfolk Regional.