TEMPE - The Cardinals thought they would have an effective running game this season with the one-two punch of Beanie Wells and Ryan Williams.

But with Monday's announcement that Williams will require season-ending surgery on his left shoulder and with Wells (turf toe) out at least five more games, it's Arizona that has taken a couple of shots to the gut.

"That's the NFL. Teams have to fight through adversity," coach Ken Whisenhunt said. "We've done a good job of that the first five weeks of the season. Now we have another challenge."

Williams, who led Arizona with 164 rushing yards, suffered a hard hit on the shoulder in the fourth quarter of Thursday's loss at St. Louis. Whisenhunt said he felt "horrible" for Williams, who missed his rookie year after tearing his patellar tendon in the preseason.

The Cardinals are left with a tailback rotation of LaRod Stephens-Howling, who has missed the past two games with a hip injury, William Powell and Alfonso Smith. Combined, the three players have 15 carries for 10 yards this season.

RG3 'looks good'

ASHBURN, Va. - Robert Griffin III felt good enough to attend a meeting Monday and seemed to be doing fine on the day after suffering his first NFL concussion.

The quarterback still has to complete the league's mandated return-to-play protocol before he's cleared for practice, but his Washington teammates and coach Mike Shanahan were optimistic the Heisman Trophy winner can play in Sunday against Minnesota.

"Right now it looks good," said Shanahan.

Griffin lost his footing while turning the corner on third-and-goal, and his helmet rammed into the upper body of Atlanta's Sean Weatherspoon.

Cassel out, Quinn in

KANSAS CITY, Mo. - The Chiefs are down to their backup quarterback for the second year in a row.

Matt Cassel sustained a concussion in the fourth quarter of Sunday's game against Baltimore and is unlikely to play in next weekend's game at Tampa Bay, which means Brady Quinn is preparing to start an NFL game for the first time in nearly three years.

Cassel hurt his throwing hand last November, undergoing surgery and landing on injured reserve.

The move to Quinn may have happened eventually. Cassel had completed only 58.5 percent of his passes with five TDs and a league-leading nine interceptions.

That's part of the reason some fans hired a plane to tow a banner pleading for Cassel to be benched, and why a small segment of the crowd at Arrowhead Stadium cheered when he got hurt - drawing the ire of right tackle Eric Winston.

Winston called it "100-percent sickening," but on Monday he clarified that he wasn't talking about all K.C. fans, just those who cheered.

Extra points

• Former Detroit All-Pro defensive lineman and actor Alex Karras, 77, has kidney failure and is in grave condition, Detroit newspapers reported. Karras, who has suffered from dementia, is among the many ex-players suing the NFL over the treatment of head injuries.

• The NFL suspended Giants rookie safety Will Hill for using Adderall, the same prescription drug stiumulant used by teammate Tyler Sash and Browns cornerback Joe Haden, who were both suspended.

• Green Bay ruled out RB Cedric Benson (sprained foot) for Sunday's game with Houston, but said tight end Jermichael Finley (shoulder) and defensive tackle B.J. Raji (ankle) might play.

• Tennessee quarterback Jake Locker will miss his second straight game with an injured left shoulder Thursday when the Titans play Pittsburgh. Backup running back Javon Ringer will miss four to six weeks after spraining his left knee.

• Bengals running back Bernard Scott will miss the rest of the season with an injured left knee.