South Prudence Road is currently restricted between East Calle La Vega and East Calle Arturo, officials say.
Crews with Tucson Fire and Southwest Gas are currently working to repair a struck gas line, officials said on Twitter. Tucson police are also on scene.
Officials responded to the scene shortly after 1:30 p.m. Friday. Prudence was originally closed between East 22nd Street and East Broadway for about an hour and a half. The break was secured shortly after 3 p.m.
It's unknown when the area will reopen. Drivers should avoid the area.