We're into the second month of the National Football League season and below are the Week 6 NFL odds for every game on the schedule. It all starts with an NFC West rivalry between the San Francisco 49ers and Seattle Seahawks on Oct. 10.
NFL Week 6 betting odds: Moneyline, spread & total for every Week 6 NFL game
Both the 49ers and Seahawks are coming off disappointing losses in Week 5 and though Seattle remains the NFC West leader through five weeks at 3-2, San Francisco (-3) is favored on Thursday night.
The 49ers were shut out in the second half at home against Arizona and turned the ball over three times in a 24-23 loss, though Brandon Aiyuk and George Kittle dominated with eight receptions each in the game. The Niners are 2-3 both in the standings and against the spread.
Seattle has covered just one game this season and is now coming off back-to-back losses after throwing in a dud at home against the Giants and allowing 175 rushing yards in the process.
The latest Jayden Daniels outing was a 34-13 win for the Commanders over the Browns, which featured 23 passing yards and 82 rushing yards for the Offensive Rookie of the Year favorite. Washington is now 4-1 on the season heading into a Week 6 affair with Baltimore.
The Ravens (-6.5) have won three games in a row, the latest being a 41-38 thriller in overtime over Cincinnati after scoring 17 points in the fourth quarter. Lamar Jackson accounted for over 400 yards and tossed four touchdowns.
Baltimore is 3-2 against the spread while Washington is 4-1 so far this season, and each team has gone over the total in four of five games as well.
The Detroit Lions (-3) are favored as they visit the Dallas Cowboys at AT&T Stadium in Week 6. Detroit is 3-1 and coming off a bye and has covered the spread in all three wins. The total for this game is set at 52 points but just one of four Lions games have gone over the total while Dallas entered Week 5 going under in three of four matchups.
Joe Burrow threw for nearly 400 yards and five touchdowns in Week 5, but it wasn't enough to keep the Bengals from coughing up a late lead and losing in OT to the Ravens. Now, they visit the Giants at MetLife Stadium on Monday Night Football as favorites (-3.5).
The Giants' defense and special teams traveled in a big way for a Week 5 win in Seattle and New York has now won two of three. That effort will go a long way against Burrow and Cincinnati's offense, although New York has yet to win a home game.
Four of five Bengals games have gone over, while four of five for Big Blue have gone under. The total is set at 48 points.
The Jets opted not to receive a bye after traveling to London and now have to welcome in the first-place Bills on Monday Night Football on the heels of two straight losses. Buffalo is also coming off a pair of losses, though the Ravens and Texans on the road aren't exactly easy games to win. Josh Allen has accounted for 10 touchdowns this season without an interceptions. New York and Buffalo are both 2-3 against the spread to this point.
NFL Week 6 betting odds: NFL betting lines for all Week 6 games
Check out Week 6 NFL betting lines for each game on the slate below:
Chicago Bears at Detroit Lions
New York Giants at Dallas Cowboys
Miami Dolphins at Green Bay Packers
Las Vegas Raiders at Kansas City Chiefs
Pittsburgh Steelers at Cincinnati Bengals
Indianapolis Colts at New England Patriots
Arizona Cardinals at Minnesota Vikings
Tennessee Titans at Washington Commanders
Los Angeles Chargers at Atlanta Falcons
Houston Texans at Jacksonville Jaguars
Tampa Bay Buccaneers at Carolina Panthers
Los Angeles Rams at New Orleans Saints
Philadelphia Eagles at Baltimore Ravens
San Francisco 49ers at Buffalo Bills
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Carter Breazeale is a contributor for Catena Media with a focus on sports, business and the business of sports. An Atlanta native currently residing in Orlando, Carter graduated from The University of Central Florida. He’s appeared in Catena’s PlayGeorgia, SB Nation’s The Falcoholic, and The Orlando Business Journal.
