Former President Joe Biden's cancer spread beyond his bones and causes him significant pain, his son Hunter Biden said in a BBC interview posted online Friday.
Former U.S. President Joe Biden gestures June 18 during a dedication ceremony for the opening of the Obama Presidential Center in Chicago, Illinois.
Hunter Biden became emotional while discussing his father's health during an interview with BBC Newsnight, saying his father's cancer "metastasized into his bones and further." He described the disease as "very painful" and "very debilitating."
"Cancer is really hard," Hunter Biden said, according to the BBC. "It's really sad to watch."
He said his father remains the center of the Biden family and praised the former president's resilience as he continues to deal with the illness.
"My dad is, to this day, the center of our family," he said. "He's the best father, the best husband, the best grandfather."
Mayo Clinic researchers have used artificial intelligence to design an experimental drug that targets a region of the GIPC1 protein long considered impossible to drug, opening a new path against pancreatic cancer. The AI-designed compound, called GIPCi, blocks the protein's PDZ domain, which helps tumors grow and resist treatment. In laboratory studies, the drug slowed tumor growth, extended survival, and boosted the effectiveness of the chemotherapy drug gemcitabine, while showing early signs of reshaping the environment around tumors. Published in Cell Reports, the findings mark one of the first examples of AI directly generating a viable small-molecule cancer drug candidate against a previously 'undruggable' target. The work remains preclinical, and researchers say further safety studies are needed before human trials can begin, but they call it a strong foundation for the next phase of research. Disclosure: This video contains stock footage and content created or enhanced using AI-assisted tools. ai-generated WooGlobe Ref : WGA897130
Joe Biden's cancer diagnosis
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Biden, 83, was diagnosed with an aggressive form of prostate cancer in May 2025 after experiencing urinary symptoms. Doctors discovered a nodule on his prostate, and the cancer already spread to his bones by the time it was detected.
The former president continues to receive treatment for the disease. His treatment included radiation and hormone therapy, which he began in October.
Biden previously said he was "feeling good" after his diagnosis and doctors expected his treatment to be effective.
Jill Biden says treatment is ongoing
Former First Lady Jill Biden speaks July 14 at The Queen in Wilmington, Del., as part of her book tour for her latest book, “View from the East Wing: A Memoir.”
Former first lady Jill Biden said Wednesday that her husband's cancer requires ongoing monitoring and treatment.
During the interview on SiriusXM's "Let's Talk Off Camera With Kelly Ripa," Jill Biden said her husband made frequent nighttime trips to the bathroom, sometimes as many as seven times a night. She said the issue continued after the couple left the White House in January 2025, prompting her to urge him to seek additional medical care.
“We have to be mindful of it every three months, testing and medicines,” she told Ripa. “And anybody who’s gone through this cancer journey — and I’ve been through it many times with members of my family, of course with Beau — it’s constant. It’s daily. And I think it’s challenging.”
Biden's oldest son, Beau Biden, died in 2015 at age 46 after battling brain cancer.
Hunter Biden did not provide additional details in the BBC interview about the extent of his father's cancer or whether his treatment changed.
Prostate cancer is the most common cancer among men in the United States aside from nonmelanoma skin cancers, according to the Centers for Disease Control and Prevention. About 1 in 8 men will be diagnosed with prostate cancer during their lifetime, according to the American Cancer Society.
